Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output
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منابع مشابه
Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output
The basic unit of genome packaging is the nucleosome, and nucleosomes have long been proposed to restrict DNA accessibility both to damage and to transcription. Nucleosome number in cells was considered fixed, but recently aging yeast and mammalian cells were shown to contain fewer nucleosomes. We show here that mammalian cells lacking High Mobility Group Box 1 protein (HMGB1) contain a reduced...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2011
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001086